Prior to the book's publication, the writer had approached the movie's producers, Andrew Macdonald and Andrew Reich, about a possible movie, and wrote the film a ninety-six page script. While initially having trouble finding an actress to play Kathy, Mulligan was cast in the role after Peter Rice, who is the head of the company financing the film, recommended her while watching her performance in An Education. A fan of the books, Mulligan ecstatically accepted the role, having hoped to play that specific character if a film adaption were to ever be made of the book, years before. The movie's message and themes were the factors that attracted Garfield to become a part of the film.
Never Let Me Go premiered at the 37th annual Telluride Film Festival in September 2010, where the audience positively responded to its message. The movie has since been screened at a number of festivals, including the 2010 Toronto International Film Festival as well as opening the 54th London Film Festival. It was distributed theatrically by Fox Searchlight Pictures in the United States on 15 September 2010, where it was given a limited release. Other release dates for the movie include a 14 January 2011, date for the United Kingdom. In the US, playing at four theatres, Never Let Me Go grossed over $111,000 in its opening weekend. As the number of theaters it played at began to expand, it continued to make more money each week, going to earn over $800,000 in total domestically. Never Let Me Go was met with mixed reviews from film critics, with most reviewers generally praising the cast's overall performances.